From Thessaloniki:
Follow the signs towards 'Egnatia Odos' and Serres. 'Lefkonas'
Village is that last settlement on your way to the city of
Serres. After Lefkonas keep driving straight ahead
following the signs towards the city of Serres. As soon as you
enter Serres Town keep on the left side of the road and keep
driving on 'Venizelou' Street. After a 5 to 10 minute drive
,depending on the traffic, you will still keep on the left side
and follow 'Ethnikis Antistasis' street. Again after
approximately 5 to 10 minutes you will notice Philippos Xenia
Hotel on your left hand at the corner with Anapafseos street.
The duration from Thessaloniki to Serres city center and
Philippos Xenia Hotel is about 1 hour and 15 minutes.
From Athens:
Simply follow the E-95 highway until you reach Thessaloniki suburbs. When you see the signs towards the Ring Road of Thessaloniki and Serres simply follow them and enter the Ring Road. Afterwards simply follow the signs towards the city of Serres. As soon as you enter Serres Town keep on the left side of the road and keep driving on 'Venizelou' Street. After a 5 to 10 minute drive, depending on the traffic, you will still keep on the left side and follow 'Ethnikis Antistasis' street. Again after approximately 5 to 10 minutes you will notice Philippos Xenia Hotel on your left hand at the corner with Anapafseos street. The duration from Thessaloniki to Serres city center and Philippos Xenia Hotel is about 1 hour and 15 minutes.